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New Novartis Patent: Final.





Patent WO9935913 is built up as follows:
p1-6: description of the "invention" and of the advantageous properties.

p6-57: Table A: a list of all kind expressed principles (Herbicide,
insect, virus, fungal etc. resistancies) and corresponding crop
phenotypes/tolerances.
p 57-63: crops to which the "invention" can be applied, auxiliary
substances that can be used and diffrent kind of apllication methods
(sprays, powders, granules etc.)
p63-83: Table B: listing of range of working of different Insecticidal
Resistancies (Bt. etc.)
p83-90: Methods for Table B. (see below)
p90-94: Table C: List of different Herbicide Resistancies.
p94-121:Methods for table C (see below)
p121-129: Biological Examples
p.130: Claims

Some additional info on HR crops.
First, in part IV one class of HR crops was forgotten:
Class 9) HPPD = Hydroxphenylpyruva: dioxygenase
Gives tolerance to: Iaoxazoles such as Isoxaflutol, Isoxachlotol.
Triones such as Sulcotrion, Mesotrion.

A correction for PROTOX: In stead of dioheny it should read:
diphenylethers.

In table A some more herbicides are mentioned:
For PROTOX: phenylpyrazoles, phenopylate
For ALS: phtalides, pyrimidyloxybenzotes
For ACCase: Aryloxyphenoxyalkanecarbolyxic acids, cyclohexanediones.
Resistance to Sulfonylureas can also be obtained by Cytochrome P450 eg
P450 SU1 which also gives resitance to Xenobiotics.

Table A describes resistancies for the following crops: Maize, wheat,
barley, soy, potatoes, tomatoes, peppers, grapes, pome fruits, Brassica
vegetables, Oil Seed rape, sugarcane, cotton, banana, melons,
sugarbeet-beetroot, sunflowers.

A typical Method as described in p83-90 (variation only in crop and
apllied substance)   is as follows:
A method of controlling pests comprising the application of thiamethoxam
to transgenic rice weherein the combination of the active principle
expressed by the transgenic plant and the pest to be controlled
correspond to anyone of the indiviualised combinations of Table B.

For the methods of p.94-121 (the variation is in target insects and
applied substance)
it reads:
A method of controlling representatives of the genus Ephestia comprising
the application of Ti-435 to a herbicidically resistant transgenic crop
wherein the combination of the active principle expressed by the
transgenic plant and the crop to be protected against the pest
correspond to anyone of the lines of Table C.

On page 59-60 it states: "It has emerged that the method according to
the invention is valuable preventatively and/or curatively in the field
of pest control even at low use concentrations of the pesticidal
composition and that a very favourable biocidal spectrum is achieved
thereby. Combined with a favourable compatibility of the composition
employed with warm blooded species, fish and plants, the method
according to the invention can be employed against all or individual
stages of normally sensitive, but also of normally resistant animal
pests such as insects and representatives of the oreder Acarina,
depending on the species of the transgenic crop plant to be protected
from attack by pests.
The insecticidal and/or acaricidal effect of the method according to the
invention may become apparent directly, i.e in a destruction of the
pests which occurs immediately or only after some time has elapsed, for
example, during codysis(?WdL), or indirectly, for example as a reduced
oviposition and/or hatching rate, the good action corresponding to a
destruction rate (mortality) of at least 40-50%".

The application was filed 14 january 1999.
Title of the Patent: The use of Neonicodinoids on transgenic plants.

End.
Wytze