2-Plants: U.S. scientists find blight-resistant gene in wildMexican potato
- To: GENET-news <GENETfirstname.lastname@example.org>
- Subject: 2-Plants: U.S. scientists find blight-resistant gene in wildMexican potato
- From: GENET <email@example.com>
- Date: Tue, 29 Jul 2003 16:01:42 +0200
- Content-Transfer-Encoding: 7bit
- Content-Type: text/plain; charset=US-ASCII
- Reply-To: firstname.lastname@example.org
- Sender: email@example.com
genet-news mailing list
-------------------------------- GENET-news -------------------------------
TITLE: SCIENTISTS FIND GENE THAT PROTECTS AGAINST POTATO BLIGHT
SOURCE: The University of Wisconsin, USA, News Releases
DATE: Jul 14, 2003
------------------- archive: http://www.genet-info.org/ -------------------
SCIENTISTS FIND GENE THAT PROTECTS AGAINST POTATO BLIGHT
MADISON - Scouring the genome of a wild Mexican potato, scientists have
discovered a gene that protects potatoes against late blight, the
devastating disease that caused the Irish potato famine.
The discovery of the gene and its cloning by scientists at the University
of Wisconsin-Madison was reported today (July 14) in online editions of
the Proceedings of the National Academy of Sciences (PNAS).
The identification of the gene, found in a species of wild potato known
as Solanum bulbocastanum, holds significant potential. All of the
varieties now cultivated commercially on more than 1.5 million acres in
the United States are highly susceptible to potato late blight, a family
of fungal pathogens that wreaks havoc in the field, turning tubers to
mush and invariably killing any plant it infects.
"We think this could be very useful," says John Helgeson, a UW-Madison
professor of plant pathology, a research scientist with the U.S.
Department of Agriculture and a senior author of the PNAS paper. "No
potato grown in the United States on any scale at all has resistance to
With the blight-resistant gene in hand, the Wisconsin team, which also
includes Jiming Jiang, a UW-Madison professor of horticulture, was able
to engineer plants that survived exposure to the many races of
Phytophthora infestans. The insertion of a single gene, according to
Jiang and Helgeson, effectively protects plants from the range of late
"So far, the plants have been resistant to everything we have thrown at
them," says Helgeson.
The world's most serious potato disease, late blight is best known as the
cause of the Irish potato famine. Seeming to appear from nowhere in 1845,
the fungus wiped out the staple crop of the densely populated island
nation, causing mass starvation over five years, killing more than a
million people and sparking a wave of immigration that had worldwide
More than 150 years later, Ireland's population has yet to return to pre-
Prior to the 1990s, chemical fungicides were available in the United
States and effectively held the disease at bay. But new strains of the
pathogen have emerged, testing the limits of the technology and requiring
American farmers to treat potato fields as many as a dozen times a season
at a cost of up to $250 per acre. In warmer climates such as Mexico,
fields may be treated as many as 25 times a year with the costly and
"We used to be able to get by, but the new (late-blight) strain just
levels things in no time at all," says Helgeson.
The gene that protects potatoes from the fungus comes from a plant that
scientists believe co-evolved in Mexico alongside the late-blight
pathogen. It was discovered, ironically, as a result of the emergence of
a new strain of P. infestans that swept through the United States in
1994. At UW-Madison's Hancock Agricultural Research Station, the only
plants to survive were the wild Mexican species and its progeny in
Helgeson's test plots.
Subsequent to the 1994 outbreak, which required the development of new
fungicides for agriculture, Helgeson and his colleagues began the hunt
for the genes that conferred resistance on the wild Mexican cousin of the
domesticated tubers familiar to consumers.
In 2000, Helgeson's lab reported narrowing the search to one of the 12
chromosomes of the wild plant. Now, with the gene identified, cloned and
successfully tested in engineered varieties in the laboratory, at hand is
a new technology that could save farmers hundreds of millions of dollars
and benefit the environment by eliminating the application of thousands
of tons of toxic chemicals.
But despite the huge economic and environmental gains that could be
realized, it is unclear if the technology will be widely utilized.
Because of European fears of genetically modified crops, and the control
exercised over growers by a few large buyers, there is currently no
engineered potato in commercial production anywhere.
The use of conventional breeding techniques to move the newfound blight-
resistance gene into the few dominant commercial varieties popular in the
United States is all but impossible, according to Jiang.
"We can do it by conventional breeding, but we can't move it into the
standard cultivated varieties without losing them," he says. "It is
almost impossible to create another Burbank variety, for example, through
conventional breeding. Your odds of getting the one gene in would be like
winning the lottery."
Still, the Wisconsin group, plans to develop engineered varieties for the
garden. The hope, they say, is to develop the technology that will
gradually win consumer acceptance and, perhaps someday, go where no GMO
has gone before.
The lead authors of the PNAS paper published today are Junqi Song of the
UW-Madison Department of Horticulture and James M. Bradeen of the UW-
Madison Department of Plant Pathology and the U.S. Department of
Agriculture's Agricultural Research Service. Other co-authors include S.
Kristine Naess and Geraldine T. Haberlach of the UW-Madison Department of
Plant Pathology and the U.S. Department of Agriculture's Agricultural
Research Service, John A. Raasch and Sandra Austin-Phillips of the UW-
Madison Biotechnology Center, Susan M. Wielgus of the UW-Madison
Department of Horticulture, Jia Liu and C. Robin Buell of the Institute
for Genomic Research in Rockville, Md., and Hanhui Kuang of the
Department of Vegetable Crops at the University of California at Davis.
- Terry Devitt (608) 262-8282, firstname.lastname@example.org
Jiming Jiang (608) 262-1878, email@example.com
John Helgeson (608) 262-0649, firstname.lastname@example.org
Note to editors: A high-resolution image showing the gene's effects is
European NGO Network on Genetic Engineering
Hartmut MEYER (Mr)
Kleine Wiese 6
D - 38116 Braunschweig